Composition

Each ampoule of Tationil contains 600 mg of reduced Glutathione in 4 ml of sterile solution. The package includes 10 ampoules and 10 corresponding vials of diluent for reconstitution. Other excipients include sodium hydroxide for pH adjustment and water for injections.

Description

Tationil is a pharmaceutical-grade Glutathione product used for antioxidant support, detoxification, and skin health. Glutathione is a naturally occurring tripeptide composed of glutamine, cysteine, and glycine. It plays a vital role in cellular defense, free radical neutralization, and metabolic regulation.

Indications

• Supportive treatment for liver detoxification
• Adjunct therapy in chemotherapy-induced toxicity
• Immune system support in chronic illness
• Adjunct in treatment of chronic fatigue syndrome and neurodegenerative diseases
• Skin brightening (off-label use under medical supervision)

Pharmacological Action

Glutathione acts as a potent antioxidant by reducing reactive oxygen species (ROS), maintaining redox balance, and detoxifying xenobiotics through conjugation. It is involved in DNA synthesis, protein repair, and immune regulation.

Dosage and Administration

• Route: Intravenous (IV) or intramuscular (IM) injection only
• Typical Dosage: 600 mg to 1200 mg 1–3 times per week, depending on indication and physician’s guidance
• Preparation: Reconstitute lyophilized powder with provided diluent before administration

Contraindications

• Known hypersensitivity to Glutathione or excipients
• Asthma (due to rare reports of bronchospasm)
• Severe renal or hepatic impairment unless prescribed under strict medical supervision

Warnings and Precautions

• Use caution in patients with renal insufficiency
• Monitor liver enzymes and renal function in long-term use
• IV use should only be done in a clinical setting by trained professionals

Adverse Reactions

• Common: Headache, dizziness, mild gastrointestinal discomfort
• Local: Injection site pain or irritation
• Rare but serious: Allergic reactions, bronchospasm, rash, or anaphylaxis

Drug Interactions

• May interact with chemotherapy agents; consult an oncologist before use
• May reduce oxidative stress markers, which could alter the efficacy of certain pro-oxidant therapies

Pregnancy and Lactation

There is insufficient data on the safety of Glutathione during pregnancy and breastfeeding. Use only if clearly necessary and under medical supervision.

Overdose

Symptoms may include gastrointestinal upset, headache, dizziness, or hypotension. Supportive care is recommended. Seek immediate medical attention in case of overdose.

Storage Conditions

• Store at 15°C to 25°C (59°F to 77°F)
• Protect from direct light and moisture
• Do not freeze
• Use immediately after reconstitution; discard any unused solution

Scientific References

• Therapeutic applications of Glutathione – PubMed
• Glutathione: Overview of its clinical applications – NCBI

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