ACTOVEGIN – Extract from Calves’ Blood

Composition and Product Form

Actovegin solution for Injections: Each 10 ml ampoule contains 400 mg of deproteinized hemoderivative from bovine blood. Pack includes 5 ampoules.

Solution for Infusion 10% and 20%: Each vial of 250 ml contains deproteinized hemoderivative from calf blood, 1 g and 2 g respectively, with sodium chloride.

Solution for Infusion 10% with Glucose: Each vial of 250 ml contains deproteinized hemoderivative from calf blood of 1 g.

Pharmacological Effect

Antihypoxant: ACTOVEGIN is a hemoderivative obtained by dialysis and ultrafiltration, with a positive effect on glucose delivery and utilization. It stabilizes plasma membranes of cells during ischemia, reducing lactate formation. Its antihypoxic effect begins within 30 minutes after use, peaking at 3 hours.

Pharmacokinetics

ACTOVEGIN’s physiological components make pharmacokinetic studies infeasible.

Recommendations for Use in Sports

• Enhances recovery after endurance-focused stresses.
• Prevents and treats dystrophic chronic physical overstrain of the cardiovascular system, especially in mid-altitude training.
• Maintains performance during high-altitude ascents.
• Useful for achillodynia, muscle tears, traumatic brain injury, and more.

Method of Use and Dosage

Administer intra-arterial, intravenous, or intramuscularly. Perform a trial injection before infusion due to potential anaphylactic reactions.

Initial dosage: 10-20 ml/day intravenously or intra-arterially; then 5 ml intravenously or 5 ml intramuscularly. For infusion, mix 10-20 ml with 200-300 ml of sodium chloride solution or dextrose solution. Injection rate: approximately 2 ml/min.

Contraindications

Do not use if hypersensitive to ACTOVEGIN, have decompensated cardiac insufficiency, or fluid retention. Caution with hyperchloremia and hypernatremia.

Side Effects

Allergic reactions may occur, ranging from skin rash to anaphylactic shock.

Medication Interactions

Interactions currently unknown.

Special Instructions

For intramuscular use, inject no more than 5 ml slowly. Conduct a trial injection (2 ml intramuscularly) to check for anaphylactic reactions.

Solution for injections may vary in color intensity but does not affect medication activity or tolerance. Do not use cloudy or particle-containing solutions.

After opening, do not store the solution.

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