Description

ACTOVEGIN Tablets, 200 mg, #50

Composition and Form of Release

Actovegin Dragee: Each dragee contains 200 mg of deproteinized hemoderivative from calf blood. The package contains 50 dragees.

Pharmacological Effect

Antihypoxant. This hemoderivative is obtained through dialysis and ultrafiltration, allowing compounds with a molecular weight of less than 5000 daltons to pass. It has a positive impact on glucose transport and utilization, stimulates oxygen consumption (which stabilizes cell plasma membranes during ischemia and reduces lactate formation), thus providing an antihypoxic effect. This effect becomes evident no later than 30 minutes after parenteral administration and reaches its peak after an average of 3 hours (2-6 hours). It increases the concentrations of adenosine triphosphate, adenosine diphosphate, phosphocreatine, as well as amino acids such as glutamate, aspartate, and gamma-aminobutyric acid.

Pharmacokinetics

The pharmacokinetic properties of the drug cannot be studied using pharmacokinetic methods since it consists only of physiological components that are typically present in the body.

Recommendations for Use in Sports

• Acceleration of recovery processes following endurance-focused stresses.
• Prevention and treatment of the dystrophic variant of chronic physical overstrain of the cardiovascular system (especially during training at moderate altitudes).
• Maintenance of a high level of performance during high-altitude ascents.
• Treatment of Achillodynia and muscle tears.
• Management of traumatic brain injury.
• Treatment of boxers’ cerebral insufficiency syndrome.
• Treatment of frostbite in winter sports athletes.
• Promotion of weight gain.
• Prevention and treatment of sports pseudonephropathy.

Method of Administration and Dosage

Orally, take 1-2 tablets three times a day (600-1200 mg/day). The duration of treatment is 4 to 6 weeks.

Contraindications

• Hypersensitivity to the drug.
• Decompensated heart failure.
• Fluid retention in the body.
• Exercise caution in the case of hyperchloremia and hypernatremia.

Side Effects of Actovegin

Allergic reactions such as skin rash, skin flushing, hyperthermia, and in rare cases, anaphylactic shock.

Drug Interactions

Currently, there is limited information on drug interactions.

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Actovegin in the management of patients after ischemic stroke: A systematic review