Description
Hepaval (Glutathione) Ampoules 600 mg, #10 Solution
Composition
Each ampoule of Hepaval contains 600 mg of glutathione as the active ingredient. Glutathione is a naturally occurring tripeptide with strong antioxidant properties, playing a crucial role in detoxification, immune function, and cellular protection. Inactive ingredients include Sodium Hydroxide, Hydrochloric Acid (for pH adjustment), and Sterile Water for Injection.
Pharmacological Group
Hepaval belongs to the group of hepatoprotective and antioxidant agents. It acts primarily by neutralizing free radicals, supporting the detoxification of harmful substances in the liver, and boosting cellular defense mechanisms.
Therapeutic Indications
- Liver detoxification support in chronic liver diseases (e.g., hepatitis, cirrhosis, steatosis)
- Adjunct therapy for alcoholic liver disease and drug-induced liver toxicity
- Antioxidant support in individuals exposed to oxidative stress or environmental toxins
- Immunomodulatory support for patients with chronic illnesses
- Aesthetic medicine (off-label): skin brightening and anti-aging therapy (under clinical discretion)
Mechanism of Action
Glutathione acts as a key component in the cellular antioxidant defense system. It protects hepatocytes and other cells by directly scavenging reactive oxygen species (ROS), regenerating other antioxidants like vitamin C and E, and supporting phase II liver detoxification enzymes. It also aids in the metabolism of xenobiotics, heavy metals, and peroxides.
Dosage and Administration
- Route: Intravenous injection (IV push or IV drip)
- Recommended Dose: 600 mg once daily (1 ampoule), administered slowly under sterile conditions
- Treatment Duration: Typically 5–10 days or as advised by the healthcare provider
- Note: Only for use under medical supervision
Contraindications
- Hypersensitivity to glutathione or any excipients
- Use in pregnancy and lactation without medical consultation
- Patients with unstable renal or hepatic insufficiency
Precautions
- Monitor renal and hepatic function periodically during long-term use
- Not recommended for pediatric use
- Use caution in patients with asthma or sulfite sensitivity
Side Effects
- Common: Mild headache, dizziness, or injection site discomfort
- Uncommon: Gastrointestinal discomfort (nausea, abdominal pain)
- Rare: Allergic reactions such as rash, itching, swelling, or anaphylaxis
Drug Interactions
- May alter the effectiveness of chemotherapeutic agents and some immunosuppressants
- Concurrent use with high-dose antioxidants should be evaluated by a physician
Overdose
In the event of an overdose, symptoms may include nausea, vomiting, abdominal cramps, dizziness, or hypotension. Immediate medical attention is required. Treatment is symptomatic and supportive.
Storage
Store in a cool, dry place at 15–25°C (59–77°F). Protect from light and moisture. Do not freeze. Once an ampoule is opened, use immediately and discard any remaining solution.
Reviews
There are no reviews yet.