Description

Pregnyl Vials, 1500 IU, #3 Solution

Composition

Pregnyl contains the active substance human Chorionic Gonadotrophin (hCG), with each vial delivering 1500 IU. It is derived from the urine of pregnant women and purified for medical use. Inactive ingredients include mannitol and sodium phosphate, which help stabilize the solution. Each pack includes 3 vials.

Indications

• Induction of ovulation in women with infertility due to anovulation
• Support of the luteal phase in assisted reproductive technology (ART) protocols
• Treatment of male infertility due to hypogonadotropic hypogonadism (low sperm count)
• Stimulation of testosterone production in delayed puberty in boys

Dosage and Administration

Pregnyl is administered by intramuscular or subcutaneous injection. Doses should always be determined by a physician. Typical regimens include:

• Women (Ovulation Induction): 5,000 to 10,000 IU one day after the last dose of follicle-stimulating hormone (FSH) or menotropins
• Men (Hypogonadism): 500 to 1000 IU three times weekly for 3 weeks, followed by the same dose twice weekly for another 3 weeks
• Pubertal Boys: Dosage and frequency individualized by physician

Contraindications

• Known hypersensitivity to hCG or any component of the product
• Women with ovarian enlargement not caused by PCOS
• Uncontrolled thyroid or adrenal gland disorders
• Unexplained uterine bleeding
• Androgen-dependent tumors (e.g., prostate cancer in men)

Warnings and Precautions

• May increase the risk of multiple gestation (e.g., twins or triplets)
• Careful monitoring is advised in patients with heart disease, renal disease, migraines, asthma, or epilepsy
• Use in adolescent boys should be supervised to avoid premature epiphyseal closure
• Monitor ovarian response to avoid ovarian hyperstimulation syndrome (OHSS)

Side Effects

Common side effects include:

• Headache
• Irritability
• Fatigue
• Localized swelling or pain at the injection site

Serious but less common effects include:

• Ovarian hyperstimulation syndrome (OHSS)
• Weight gain
• Lower abdominal or pelvic pain
• Edema or shortness of breath

Interactions

No major interactions are widely documented, but concurrent use with gonadotropins or fertility medications may amplify ovarian response. Always inform your physician of any ongoing medications or supplements.

Storage

• Store in a refrigerator between 2°C and 8°C (36°F to 46°F)
• Do not freeze
• Keep vials in the original packaging to protect from light
• Keep out of reach of children

Scientific References

• Practice Committee of the ASRM. Use of hCG in infertility treatment – PubMed
• Pregnyl Prescribing Information – Drugs.com

Conclusion

Pregnyl is an effective medication used in the treatment of infertility in both men and women, as well as in the stimulation of testosterone in boys with delayed puberty. It must be administered under medical supervision with regular monitoring to ensure safety and efficacy.