Description

Samyr 400 mg – 20 Capsules

Composition

Each capsule contains Ademetionine 1,4-butanedisulfonate equivalent to 400 mg of S-Adenosyl-L-methionine (SAMe). Excipients include microcrystalline cellulose, magnesium stearate, and colloidal anhydrous silica.

Description

Samyr 400 mg comes in the form of hard gelatin capsules filled with a white to off-white powder. Capsules are packaged in blister strips with 20 units per pack.

Indications

Samyr is indicated for:

• Major depressive disorder (MDD)
• Chronic liver diseases (e.g. intrahepatic cholestasis, cirrhosis)
• Osteoarthritis with inflammatory components
• Supplementation in cases of SAMe deficiency

Mechanism of Action

S-Adenosyl-L-methionine (SAMe) is a naturally occurring methyl donor involved in the synthesis of neurotransmitters (e.g. serotonin, dopamine), phospholipids, and glutathione. It exerts antidepressant and hepatoprotective effects, along with anti-inflammatory activity beneficial in osteoarthritis.

Dosage and Administration

• Standard dose: 400 mg (1 capsule) twice daily on an empty stomach
• Severe depression or hepatic conditions: Up to 800 mg twice daily
• Swallow whole with water; do not crush or chew

Contraindications

• Known hypersensitivity to SAMe or formulation ingredients
• History of bipolar disorder (risk of manic switch)
• Use in children and adolescents under 18 years is not recommended

Precautions

• Monitor liver function during prolonged treatment
• Use with caution in elderly or psychiatric patients
• Inform healthcare provider about gastrointestinal or renal disorders

Side Effects

• Common: Nausea, diarrhea, abdominal pain
• Less common: Insomnia, dizziness, dry mouth
• Rare: Allergic skin reactions (rash, itching)

Overdose

Symptoms may include gastrointestinal discomfort, nausea, and vomiting. In case of overdose, provide supportive treatment and consult a healthcare provider immediately.

Drug Interactions

• Use with serotonergic agents (SSRIs, MAOIs) may increase risk of serotonin syndrome
• May potentiate the effect of other antidepressants
• Discuss all current medications with your doctor before use

Pregnancy and Lactation

• Use during pregnancy only if clearly needed and under medical supervision
• Safety during lactation is not well established; caution is advised

Storage

Store below 25°C (77°F) in a dry place away from moisture and direct sunlight. Keep out of reach of children.

Scientific References

• Ademetionine in major depressive disorder – PubMed
• SAMe in liver disease and depression – NCBI

Disclaimer

This summary is for informational purposes only and does not replace medical advice. Always consult your healthcare provider before starting any medication.