Composition

Each 50 ml ampoule of Pascorbin contains:

• Ascorbic Acid (Vitamin C): 7.5 g
• Sodium Metabisulfite
• Sodium Hydroxide (for pH adjustment)
• Water for injection

Indications

Pascorbin is used for:

• Prevention and treatment of vitamin C deficiency
• Therapy for scurvy
• Supportive treatment in infections, fatigue, wound healing, and oxidative stress
• Adjuvant therapy in chronic inflammatory diseases and during chemotherapy (under medical supervision)

Pharmacological Action

Ascorbic acid (vitamin C) acts as a powerful antioxidant, supports collagen synthesis, promotes immune function, improves iron absorption, and protects cells against oxidative damage. High-dose IV vitamin C has been studied for adjunctive therapy in oncology and sepsis.

Dosage and Administration

Administration should be supervised by a healthcare professional. Typical routes include:

• Intravenous (IV) infusion: Preferred for high doses
• Intramuscular (IM) or subcutaneous (SC): Used in special cases

Dosage varies based on indication and patient condition. Therapeutic ranges typically fall between 1–7.5 g daily or every few days. For some applications (e.g., integrative oncology), much higher doses may be used under supervision.

Contraindications

• Hypersensitivity to ascorbic acid or any excipients
• Severe renal dysfunction or history of oxalate kidney stones
• Iron overload disorders (e.g., hemochromatosis)
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency (risk of hemolysis at high doses)

Precautions

• Monitor renal function and oxalate levels in long-term or high-dose use
• Avoid rapid IV push due to risk of hypotension or venous irritation
• Use cautiously in diabetics — high doses may affect glucose test results

Adverse Effects

• Common: Nausea, diarrhea, abdominal discomfort
• Less common: Pain at injection site, flushing, headache
• Rare: Kidney stones, hemolysis (in G6PD deficiency), allergic reactions

Drug Interactions

• May interfere with lab tests for glucose, creatinine, or occult blood
• May increase iron absorption; caution in patients with iron overload
• Concurrent use with anticoagulants or chemotherapeutic agents should be medically supervised

Pregnancy and Lactation

Pascorbin should be used during pregnancy or breastfeeding only if clearly needed and prescribed by a physician. Excessive doses should be avoided.

Storage

• Store between 2°C and 25°C (36°F–77°F)
• Protect from light and heat
• Keep out of reach of children

Scientific References

• High-dose vitamin C in sepsis – PubMed
• Intravenous vitamin C in cancer therapy – NCBI

Disclaimer

This information is intended for healthcare professionals and does not replace medical consultation. Always follow the advice and prescription of your healthcare provider when using Pascorbin.

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