Manufacturer

• Produced by: Industria Farmaceutica Galenica Senese (IFGS).
• Country of Origin: Italy
• Distributed by: Authorized distributors worldwide, depending on the region.

Composition

• Each 4 ml vial contains:
  • Active ingredient: Glutathione (reduced form) – 600 mg
  • Other ingredients: Sodium hydroxide (for pH adjustment) and water for injection

Indications

TAD-600 (Glutathione) is a powerful antioxidant used in various clinical applications to protect cells from oxidative stress and support detoxification processes. Indications include:

• Management of liver diseases, including alcoholic liver disease, fatty liver, and hepatitis
• Detoxification support for patients exposed to toxins, heavy metals, or chemotherapy
• Adjunct therapy in neurodegenerative diseases, such as Parkinson’s disease
• Skin brightening (off-label use in some regions)
• Supportive therapy in chronic fatigue syndrome and oxidative stress-related conditions

Dosage and Administration

• Administration route: Intravenous (IV) or intramuscular (IM)
• Dosage:
  • For liver support: 600 mg IV/IM daily or as prescribed
  • For detoxification: 600–1200 mg IV, 2–3 times per week
  • For skin brightening (off-label): 600–1200 mg IV once or twice weekly, often combined with Vitamin C
• Preparation: Reconstitute the powder with 4 ml of sterile diluent. Use immediately after preparation
• Duration of therapy: Varies by condition (weeks to several months)

Contraindications

• Known hypersensitivity to glutathione or any formulation component
• Use in pregnancy or breastfeeding without medical supervision
• History of severe allergic reactions to similar substances

Precautions and Warnings

• Caution in renal impairment due to risk of accumulation
• Monitor liver function tests regularly
• Do not use as monotherapy in severe disease states
• Asthmatic patients may be at risk of bronchospasm
• Off-label use (e.g., skin whitening) requires medical oversight

Adverse Effects

• Local reactions: Pain, swelling, redness at injection site
• Allergic reactions: Rash, itching, rarely anaphylaxis
• Respiratory: Mild bronchospasm (rare)
• Neurological: Headache or dizziness (rare)

Drug Interactions

• May potentiate effects of certain chemotherapeutic agents – consult oncology specialist
• No significant interactions known, but always disclose all medications to the healthcare provider

Pregnancy and Lactation

Use only under medical advice if pregnant or breastfeeding. Safety profile not well-established in these populations.

Overdose

Symptoms such as nausea, vomiting, or dizziness may occur. Typically self-limiting. Provide supportive care if needed.

Storage

• Store at 15–25°C (59–77°F)
• Protect from moisture and light
• Do not freeze
• Use reconstituted solution immediately

Scientific References

• Glutathione and liver disease – clinical significance
• Antioxidant properties of glutathione and its clinical applications

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