Description

Ascorbic Acid Vials 100 mg/ml, 2 ml, #10 Solution

Composition

Each 2 ml vial contains 100 mg/ml of ascorbic acid (Vitamin C), resulting in a total of 200 mg per vial. The solution is clear, colorless to slightly yellow, and is packaged in sets of 10 vials per box.

Description

Ascorbic Acid (Vitamin C) is a water-soluble vitamin essential for numerous physiological processes. It plays a central role in collagen synthesis, immune function, wound healing, iron absorption, and the maintenance of skin, bones, and connective tissues. As a potent antioxidant, it helps neutralize free radicals and supports the body’s detoxification mechanisms.

Pharmacology

Ascorbic acid functions as a reducing agent and antioxidant in biological systems. It is involved in oxidation-reduction reactions, collagen hydroxylation, synthesis of neurotransmitters, and immune defense. It also supports metabolic pathways including tyrosine metabolism and the synthesis of folic acid derivatives, lipids, and proteins.

Pharmacokinetics

Ascorbic acid is rapidly absorbed from the gastrointestinal tract and distributed to most body tissues. It accumulates in high concentrations in the adrenal glands, pituitary gland, retina, and leukocytes. Excess amounts are excreted via the urine. At plasma concentrations exceeding 1.4 mg/100 mL, renal tubular secretion is reduced, and urinary excretion increases.

Indications

• Prevention and treatment of Vitamin C deficiency (Scurvy)
• Supportive therapy for infections and inflammatory diseases
• Enhancement of wound healing, tissue repair, and fracture recovery
• Treatment of methaemoglobinaemia and anemia
• Adjunct in common cold, respiratory conditions, and fatigue
• General dietary supplementation

Contraindications

• Hypersensitivity to ascorbic acid or excipients in the formulation
• Patients with oxalate kidney stones or severe renal disease
• Patients with hemochromatosis or other disorders of iron metabolism

Side Effects

Most individuals tolerate ascorbic acid well. However, potential side effects include:

• Gastrointestinal discomfort: nausea, diarrhea, stomach cramps, heartburn
• Allergic reactions: rash, itching, or swelling
• Kidney-related effects: nephrolithiasis (especially with prolonged high doses)
• Iron overload in predisposed individuals due to increased iron absorption

Drug Interactions

• May interfere with anticoagulants and antiplatelet drugs
• May reduce the effectiveness of chemotherapy agents (e.g., bortezomib)
• Can affect certain lab tests (e.g., blood and urine glucose measurements)
• May increase aluminum absorption from antacids

Dosage and Administration

The typical adult dosage ranges from 500 mg to 1,000 mg per day, administered via intramuscular, subcutaneous, or intravenous injection, depending on clinical indication. Doses up to 2,000 mg per day may be used in cases of severe deficiency. Pediatric doses should be determined by a healthcare provider.

Overdose

High doses of ascorbic acid may cause gastrointestinal disturbances (nausea, vomiting, diarrhea), kidney stones, and osmotic diuresis. Chronic overdose can exacerbate iron overload in susceptible individuals. In cases of suspected overdose, discontinue administration and initiate symptomatic treatment.

Storage

• Store in a cool, dry place at temperatures below 25°C
• Protect from heat, light, and moisture
• Do not freeze
• Keep out of reach of children and pets

Precautions

• Use with caution in individuals with kidney stones or renal insufficiency
• Patients with iron storage disorders should avoid high doses
• Pregnant or lactating women should consult a doctor before use
• Prolonged high-dose administration may require periodic renal monitoring

Scientific References

• Vitamin C: A review of its role in health and disease – PubMed
• Therapeutic uses of high-dose vitamin C – PMC