Description

Аscorbic acid Vials 100 mg/ml, 2ml Ampoules, Pack of 10

Composition

Each 2 ml ampoule contains 200 mg of Ascorbic Acid (Vitamin C), equivalent to 100 mg/ml. Excipients may include sodium bicarbonate and water for injections to maintain pH stability and solubility. Supplied in packs of 10 sterile ampoules.

Description

Ascorbic acid is a vital water-soluble antioxidant vitamin that plays a key role in collagen synthesis, immune system modulation, wound healing, and iron absorption. It protects cells from oxidative damage by scavenging reactive oxygen species and is essential for the enzymatic hydroxylation of proline and lysine during collagen production. Humans cannot synthesize vitamin C endogenously and require dietary or supplemental sources to prevent deficiency.

Indications

• Prevention and treatment of scurvy
• Supportive therapy during infectious diseases or high metabolic demand (e.g., burns, trauma, surgery)
• Vitamin C deficiency due to malabsorption, alcoholism, or dietary insufficiency
• Adjunct therapy in iron-deficiency anemia to enhance iron absorption
• Supportive care in wound healing and tissue repair

Аscorbic Acid Dosage and Administration

Ascorbic acid solution is administered intravenously (IV) or intramuscularly (IM) under medical supervision. Typical dosing:

• Prevention (scurvy): 50–100 mg daily
• Treatment (scurvy or deficiency): 250–1000 mg per day in divided doses
• Severe cases (e.g., wound healing, infections): Up to 2–4 grams daily in hospital settings

Dosing should always be individualized and adjusted by a healthcare professional based on clinical needs and response.

Contraindications

• Known hypersensitivity to ascorbic acid or formulation components
• History of oxalate kidney stones
• Iron overload disorders (e.g., hemochromatosis, hemosiderosis)

Precautions

• Use cautiously in patients with renal insufficiency due to risk of oxalate nephropathy
• High-dose vitamin C may interfere with glucose and creatinine assays
• Can enhance iron absorption; monitor ferritin and transferrin saturation if combined with iron therapy
• Pregnancy: Use only if clearly needed. High doses are not well-studied for fetal safety

Adverse Reactions

Common side effects include:

• Gastrointestinal upset (nausea, diarrhea, abdominal cramps)
• Injection site irritation

Rare but serious reactions:

• Oxalate nephropathy or kidney stones at high doses
• Hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency

Overdose

Excessive doses may result in osmotic diarrhea, abdominal pain, and oxalate crystalluria. In G6PD-deficient individuals, hemolysis may occur. In suspected overdose, discontinue use and treat supportively.

Pharmacology

Ascorbic acid acts as a cofactor for several enzymatic reactions, particularly those involved in collagen formation, carnitine biosynthesis, and catecholamine metabolism. It enhances non-heme iron absorption and regenerates other antioxidants such as Vitamin E. It is rapidly absorbed and distributed in most tissues, with renal excretion of excess amounts.

Аscorbic Acid Drug Interactions

• May reduce the efficacy of anticoagulants like warfarin
• Can interfere with urine dipstick tests for glucose or ketones
• Enhances absorption of aluminum from antacids (avoid high doses)

Storage and Handling

• Store below 25°C (77°F), protected from light
• Do not freeze
• Discard vial if discolored or contains precipitate

Scientific References

• Vitamin C (Ascorbic Acid) – StatPearls, NCBI
• Ascorbic Acid in Health and Disease – PMC