Description
ATP (Adenosine Tri-Phosphate) 10 mg/ml, 1 ml, #10
ATP (Adenosine Tri-Phosphate) is a crucial biochemical compound involved in nearly all forms of cellular energy metabolism. This injectable formulation contains 10 mg of ATP per 1 ml ampoule and is typically provided in a pack of 10 ampoules.
Composition
- Active ingredient: Adenosine Tri-Phosphate (ATP) – 10 mg/ml
- Excipients: Water for injection, sodium chloride
Pharmacological Action
ATP serves as the main energy carrier in all living cells. It participates in signal transduction pathways and is essential for muscle contraction, neurotransmission, and various anabolic processes. Upon hydrolysis to ADP and AMP, ATP releases stored energy used by enzymes and structural proteins for biological activity.
Therapeutic Indications
- Supportive treatment in cardiovascular diseases (e.g., chronic heart failure, arrhythmias)
- Improving physical performance in states of fatigue and overwork
- Adjunct in neurological conditions with impaired energy metabolism
- Peripheral vascular diseases
Dosage and Administration
- Administered intramuscularly or intravenously by a healthcare professional
- Typical dose: 1 ml (10 mg) per day
- Duration of treatment depends on the condition and clinical response
Pharmacokinetics
ATP is rapidly metabolized upon administration. In plasma, it is quickly converted to ADP, AMP, and eventually to adenosine. The metabolic products are excreted through the kidneys. Due to rapid enzymatic degradation, ATP does not accumulate in the body.
Contraindications
- Hypersensitivity to ATP or any excipients
- Acute myocardial infarction
- Severe hypotension
- Recent stroke
- Uncontrolled arrhythmias
Precautions
- Use with caution in patients with hepatic or renal impairment
- Should be avoided in pregnancy unless absolutely necessary
- Careful monitoring of cardiovascular function is required
Side Effects
- Facial flushing
- Chest tightness or discomfort
- Bradycardia or transient heart block (with IV use)
- Nausea, headache, dizziness
- Local pain or irritation at injection site
Drug Interactions
- May potentiate effects of cardiac glycosides (e.g., digoxin)
- Should not be combined with xanthine derivatives (e.g., theophylline, caffeine)
- May interact with antihypertensives and antiarrhythmic agents
Overdose
Symptoms may include hypotension, bradycardia, syncope, and respiratory difficulty. Immediate medical intervention is required. Symptomatic treatment and supportive care should be provided.
Storage
- Store in a dry, dark place at temperatures between 15–25°C
- Do not freeze
- Keep out of reach of children
Packaging
Supplied in boxes of 10 glass ampoules, each containing 1 ml of sterile solution.
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