Description
Dona (Glucosamine) Vials 2 ml, Pack of 6 – Injectable Solution
Composition
Each 2 ml vial of Dona contains 1.5 grams of glucosamine sulfate as the active ingredient. Inactive components include sodium chloride, water for injection, and stabilizing agents to ensure sterility and pharmaceutical efficacy.
Indications
Dona injectable solution is indicated for the management of osteoarthritis symptoms such as joint pain, stiffness, and reduced mobility. It can be part of a comprehensive treatment regimen including physical therapy, lifestyle changes, and oral supplements.
Mechanism of Action
Glucosamine sulfate contributes to cartilage regeneration by stimulating the production of glycosaminoglycans and hyaluronic acid in the synovial fluid. It also exerts anti-inflammatory properties by reducing cytokine activity in the joint space.
Contraindications
- Known hypersensitivity to glucosamine or any of the excipients
- History of severe hepatic or renal impairment
- Pregnant or breastfeeding women unless clearly needed and prescribed
- Patients with shellfish allergy (glucosamine is typically derived from shellfish)
Precautions
- Use cautiously in patients with diabetes – glucosamine may affect glucose metabolism
- Monitor blood sugar levels in diabetic patients during long-term use
- May influence results of liver function tests and glucose tolerance tests
Drug Interactions
- Warfarin: Increased risk of bleeding – monitor INR regularly
- Diuretics: May reduce glucosamine efficacy
- Combining with NSAIDs or corticosteroids may increase gastrointestinal irritation
Dosage and Administration
The standard dose is one 2 ml vial administered once daily. It can be injected intramuscularly (IM) or intravenously (IV) under the supervision of a healthcare provider. The usual course of treatment lasts 4–6 weeks, depending on clinical response. Treatment may be repeated periodically.
Adverse Effects
- Common: Gastrointestinal disturbances (nausea, bloating, constipation), drowsiness, headache
- Less common: Skin reactions (rash, itching), heartburn
- Rare: Severe allergic reactions (angioedema, anaphylaxis), hepatotoxicity, palpitations
Overdose
Symptoms of overdose may include gastrointestinal discomfort, drowsiness, and fatigue. There is no specific antidote. Treatment is symptomatic and supportive. Seek medical attention in case of suspected overdose.
Storage
Store Dona vials at room temperature (15–25°C), away from heat, moisture, and direct sunlight. Do not freeze. Keep in original packaging and out of reach of children.
Manufacturer
Dona injectable solution is manufactured by Rottapharm, a reputable pharmaceutical company specializing in osteoarthritis and joint health therapies.
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