Description

Dona (glucosamine) vials 2 ml, #6

Active Substance

2 ml of solution (ampoule A) Dona contains crystalline glucosamine sulfate 502.5 mg; equivalent glucosamine sulfate 400 mg, and sodium chloride 102.5 mg;

Excipients

Lidocaine hydrochloride, water for injections;

Solvent (ampoule B) contains:

Excipients: Diethanolamine, water for injections.

Dosage Form

Solution for injection.

Main Physical and Chemical Properties

Ampoule A made of brown transparent glass contains a colorless or light brown transparent liquid without suspended particles;

Ampoule B (solvent) of colorless clear glass contains a colorless clear liquid without suspended particles;

A + B ampoule (solution for injection) is a light brown, clear solution that does not contain suspended particles.

Function in the Body

Like collagen and chondroitin sulfate, glucosamine can be naturally produced in the human body. This substance is one of the main building blocks of connective tissue – cartilage and ligaments. Glucosamine is part of cell membranes and the proteins within them. It binds cells together, making tissues stronger and more resistant to stretching.

Glucosamine is directly or indirectly involved in the formation or strengthening of the following tissues:

• Cartilage (covers articular surfaces);
• Tendons;
• Ligaments;
• Synovial fluid (nourishes cartilage and lubricates joint surfaces);
• Muscles;
• Skin;
• Bones;
• Nails and hair;
• Heart valves;
• Blood vessels.

In addition, glucosamine is actively used for the body’s immune defenses (interferon and immunoglobulins), necessary for the synthesis of hormones (gonadotropins), enzymes, and other important elements.

Use in Sports

It is known that in bodybuilding, powerlifting, and other heavy sports, training is carried out with heavy weights, which cause joint overload and microtrauma of ligaments and tendons. Studies have shown that damaged ligaments and joint surfaces require significantly higher amounts of glucosamine sulfate to maintain normal properties.

In addition to trials of the drug Dona in the treatment of joint diseases, a study was conducted in which scientists found positive effects when used in athletes with knee pain. This suggests that the supplement will be useful for other joints.

The first signs of joint dysfunction during sports include crunching, crepitation, pain, and stiffness. In these cases, it is necessary to start taking glucosamine and chondroitin. The same supplements can be used to prevent injuries, strengthen ligaments, and accelerate recovery from injuries.

Instructions and Doses

The daily recommended amount of glucosamine is 1500 mg (either 2 x 750 mg times a day or 3 x 500 mg times a day after meals or during meals). The preventive course lasts for 1 month, and the courses can be repeated 2-3 times a year. Dona can be used for the complex treatment of degenerative and inflammatory joint diseases, in combination with other drugs (anti-inflammatory drugs, steroids, etc.).

For intramuscular use! Dona is not intended for intravenous administration.

Before use, mix solution B (1 ml solvent) with solution A (2 ml solution) in one syringe.

The prepared solution of the drug is administered intramuscularly at 3 ml or 6 ml (solution A + B) 3 times a week for 4-6 weeks.

The presence of a yellowish color in ampoule A’s solution does not affect the drug’s effectiveness and tolerability.

Injections of the drug can be combined with oral administration of the drug in powder form for solution preparation.

Side Effects

According to clinical studies, glucosamine is safe, and no contraindications have been found. However, exceeding the daily dose of more than 3000 mg may lead to a decrease in the drug’s effectiveness and an increased risk of developing diabetes, as high concentrations can have a toxic effect on pancreatic cells. Additionally, side effects such as upset stomach, constipation and diarrhea, headache, and allergic rash may sometimes occur.

Conditions and Terms of Storage

Dona’s drug should be stored in a dry place out of reach of children. The shelf life of the drug is indicated on the package and does not exceed 3 years from the date of manufacture.

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Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?