Description

L-Carnitine 2 g/5 ml (5 ampoules) Solution

Composition

Each ampoule contains 2 grams of L-Carnitine in 5 ml of aqueous solution. Inactive ingredients include water for injections and stabilizers. This product is provided in packs of 5 ampoules.

Description

L-Carnitine is a naturally occurring amino acid derivative that plays a critical role in energy metabolism. It is essential for the transport of long-chain fatty acids into the mitochondria, where they are oxidized to generate energy. This injectable form is used therapeutically in cases of primary and secondary L-Carnitine deficiency.

Pharmacological Action

L-Carnitine facilitates the transport of fatty acids into mitochondria for β-oxidation, leading to ATP production. It also removes toxic acyl-CoA compounds from mitochondria, preserving cellular integrity. In clinical practice, it is used to improve cardiac performance, reduce muscle fatigue, and support neurological function.

Relevant literature: L-Carnitine in Human Health: A Review of Benefits and Adverse Effects

Indications and Usage

• Treatment of primary systemic carnitine deficiency (genetic)
• Secondary carnitine deficiency (e.g., due to valproic acid use or hemodialysis)
• Supportive therapy in cardiac ischemia, congestive heart failure
• Adjunctive use in athletic performance and fatigue management
• Neuromuscular disorders associated with mitochondrial dysfunction

Dosage and Administration

• Route: Intravenous or intramuscular injection by healthcare professionals only
• Adult dose: Typically 1–2 g once or twice daily, adjusted according to clinical need
• Pediatric use: Dosed per body weight (mg/kg/day) as prescribed

Note: Dosage must be individualized. Periodic blood monitoring may be necessary.

Contraindications

• Known hypersensitivity to L-Carnitine or formulation components
• End-stage renal disease without appropriate dialysis support

Precautions

• Monitor for symptoms of myopathy, especially in patients with renal impairment
• Use caution in patients with seizure disorders; L-Carnitine may lower seizure threshold
• Pregnant or breastfeeding women should only use under medical supervision

Side Effects

• Common: Nausea, vomiting, diarrhea, abdominal cramps
• Rare: Seizures, fishy body odor (due to TMA excretion), allergic reactions

Clinical reference: Safety and Side Effects of Oral and Intravenous L-Carnitine Therapy

Overdose and Treatment

Symptoms of overdose may include muscle weakness, hypotension, or gastrointestinal distress. Management is supportive and symptomatic. In patients with renal insufficiency, dialysis may be required to remove excess L-Carnitine.

Storage

• Store below 25°C (77°F), protected from light
• Do not freeze
• Keep out of reach of children