Description

Neoton Powder Vials 1 g, #4

Description

Neoton is an injectable form of creatine phosphate disodium salt, a compound that plays a key role in cellular energy metabolism. It is primarily used in critical care, cardiology, and post-surgical recovery to support ATP resynthesis in high-energy demand states. Each box contains 4 vials, each with 1 gram of lyophilized powder for intravenous administration after reconstitution.

Composition

• Active ingredient: Creatine phosphate disodium salt – 1 g per vial
• Excipients: Sodium hydroxide (for pH adjustment), mannitol, sterile water for injection (diluent)

Pharmacological Properties

Creatine phosphate serves as an immediate donor of phosphate groups for ATP regeneration, especially in tissues with high energy demands such as cardiac and skeletal muscle. Neoton helps to buffer cellular energy reserves, improve myocardial contractility, and mitigate ischemic damage during acute cardiovascular events or post-surgical stress.

Indications

Neoton is indicated in the following clinical scenarios:

• Acute and chronic heart failure
• Post-myocardial infarction recovery
• Ischemic heart disease (adjunctive therapy)
• Perioperative cardioprotection during heart surgery
• Rehabilitation post-trauma or extensive physical stress
• Creatine deficiency syndromes

Dosage and Administration

• Initial dosage: 1 g (1 vial) IV once daily, diluted in 100–250 ml of 0.9% NaCl or 5% dextrose
• Cardiac conditions: 2–4 g daily IV in divided doses during acute management
• Administration: Slow intravenous infusion over 30–60 minutes
• Only a healthcare professional should prepare and administer Neoton

Contraindications

• Hypersensitivity to creatine phosphate or any excipients
• Severe renal impairment or failure
• Hyperphosphatemia or disorders of phosphate metabolism

Precautions

• Monitor renal function during prolonged therapy
• Use with caution in patients on nephrotoxic drugs
• Pregnant or breastfeeding patients should use Neoton only if absolutely necessary under physician supervision

Side Effects

Neoton is generally well-tolerated. Possible adverse effects include:

• Mild: headache, flushing, nausea
• Local: pain, redness, or swelling at the injection site
• Severe (rare): arrhythmia, hypotension, allergic reaction (rash, dyspnea, angioedema)

Discontinue immediately if signs of hypersensitivity occur.

Drug Interactions

• Potential synergistic effects with cardiac glycosides (e.g., digoxin)
• May affect electrolyte balance when combined with diuretics
• Inform healthcare provider about all current medications and supplements

Overdose

Creatine phosphate overdose is rare but may present with metabolic acidosis, electrolyte imbalance, or neurological symptoms such as seizures. Immediate supportive treatment and monitoring are essential.

Storage

• Store at temperatures between 15–25°C
• Protect from moisture and light
• Do not freeze
• Use immediately after reconstitution

Packaging

Each box contains 4 sterile powder vials (1 g creatine phosphate per vial) and appropriate diluent ampoules, intended for parenteral use only.

Scientific References

• Neoton in myocardial energy metabolism – PubMed
• Creatine phosphate in cardiac surgery recovery – PubMed

Disclaimer

This product should only be administered by a qualified healthcare provider. The above information is for educational purposes only and does not substitute for medical consultation. Always follow the instructions of your doctor or pharmacist.