Description
Pascorbin – 7.5g/50ml Vitamin C Injection
Composition
Each 50 ml ampoule of Pascorbin contains:
- Ascorbic Acid (Vitamin C): 7.5 g
- Sodium Metabisulfite
- Sodium Hydroxide (for pH adjustment)
- Water for injection
Indications
Pascorbin is used for:
- Prevention and treatment of vitamin C deficiency
- Therapy for scurvy
- Supportive treatment in infections, fatigue, wound healing, and oxidative stress
- Adjuvant therapy in chronic inflammatory diseases and during chemotherapy (under medical supervision)
Pharmacological Action
Ascorbic acid (vitamin C) acts as a powerful antioxidant, supports collagen synthesis, promotes immune function, improves iron absorption, and protects cells against oxidative damage. High-dose IV vitamin C has been studied for adjunctive therapy in oncology and sepsis.
Dosage and Administration
Administration should be supervised by a healthcare professional. Typical routes include:
- Intravenous (IV) infusion: Preferred for high doses
- Intramuscular (IM) or subcutaneous (SC): Used in special cases
Dosage varies based on indication and patient condition. Therapeutic ranges typically fall between 1–7.5 g daily or every few days. For some applications (e.g., integrative oncology), much higher doses may be used under supervision.
Contraindications
- Hypersensitivity to ascorbic acid or any excipients
- Severe renal dysfunction or history of oxalate kidney stones
- Iron overload disorders (e.g., hemochromatosis)
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency (risk of hemolysis at high doses)
Precautions
- Monitor renal function and oxalate levels in long-term or high-dose use
- Avoid rapid IV push due to risk of hypotension or venous irritation
- Use cautiously in diabetics — high doses may affect glucose test results
Adverse Effects
- Common: Nausea, diarrhea, abdominal discomfort
- Less common: Pain at injection site, flushing, headache
- Rare: Kidney stones, hemolysis (in G6PD deficiency), allergic reactions
Drug Interactions
- May interfere with lab tests for glucose, creatinine, or occult blood
- May increase iron absorption; caution in patients with iron overload
- Concurrent use with anticoagulants or chemotherapeutic agents should be medically supervised
Pregnancy and Lactation
Pascorbin should be used during pregnancy or breastfeeding only if clearly needed and prescribed by a physician. Excessive doses should be avoided.
Storage
- Store between 2°C and 25°C (36°F–77°F)
- Protect from light and heat
- Keep out of reach of children
Scientific References
Disclaimer
This information is intended for healthcare professionals and does not replace medical consultation. Always follow the advice and prescription of your healthcare provider when using Pascorbin.
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