Description

Polyoxidonium Tablets 12 mg – Pack of 10

Composition

Each tablet contains:

Azoximer bromide – 12 mg (active ingredient)
Excipients: Lactose monohydrate, Povidone K30, Magnesium stearate, stabilizers

Pharmacological Group

Polyoxidonium belongs to the class of immunomodulatory drugs that enhance both innate and adaptive immune responses. It is used as an adjunct in the treatment and prevention of infectious and inflammatory conditions.

Mechanism of Action

Azoximer bromide acts as an immunostimulant and detoxifying agent. It enhances phagocytic activity, increases the production of interleukin-1 and interferon, and promotes antibody formation. It also improves resistance to infections and reduces the immunosuppressive effects of chemotherapy, radiation, and prolonged antibiotic use.

Indications

Polyoxidonium is indicated in adults as part of complex therapy for:

Chronic and recurrent infections (e.g., respiratory tract, ENT diseases, urogenital infections)
Secondary immunodeficiency states
Oncological diseases (to mitigate immunosuppression during chemotherapy or radiotherapy)
Post-surgical recovery to prevent complications
Burns, injuries, and recovery from severe illness

Dosage and Administration

Standard adult dosage: 1 tablet (12 mg) once daily sublingually or bucally. Duration: 5 to 30 days depending on the condition and treatment plan. The tablet should be kept in the mouth until fully dissolved; do not swallow whole or chew.

Contraindications

Hypersensitivity to Azoximer bromide or excipients
Pregnancy and lactation (due to limited clinical data)
Children under 18 years of age (for this dosage form)

Precautions

Use with caution in patients with lactose intolerance
Alcohol consumption is not recommended during the course of treatment
Care should be taken when performing activities requiring attention and coordination

Side Effects

Polyoxidonium is generally well tolerated. Rare side effects include:

Skin rash, urticaria, itching
Fever or malaise (rare)

If side effects occur, discontinue the drug and consult your physician.

Overdose

No cases of overdose have been reported. In case of accidental overdose, symptomatic treatment and observation are advised.

Drug Interactions

Polyoxidonium does not negatively interact with most pharmaceutical agents. It is often used in combination therapy, including with antibiotics, antivirals, antifungals, and cytostatics. Always inform your doctor of any other medications being taken.

Clinical Evidence

Storage

Store at room temperature (below 25°C)
Protect from moisture and light
Keep out of reach of children

Shelf Life

3 years from the date of manufacture. Do not use after expiration date indicated on the package.

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