Description

Thiamine hydrochloride (vit B1) 50 mg/ml, 1ml #10

Active Ingredient

Active ingredient: Thiamine hydrochloride

1 ml of solution contains 50 mg of thiamine hydrochloride

Inactive ingredient: Unitiol, water for injection

Pharmaceutical Dosage Form

Pharmaceutical dosage form: Injections

Basic Physical and Chemical Properties

Clear, colorless, or slightly yellowish liquid with a weak characteristic odor.

Thiamine Hydrochloride General Information

Thiamine hydrochloride is one of the 8 vitamins in the B-group. It plays a vital role in metabolic processes, stimulates growth, development, and stable digestion. Deficiency of this active component can lead to severe nerve disorders and disruptions in the functioning of the entire organism.

Let’s explore the properties, characteristics, and value of this vitamin, understand its systemic and periodic deficiency effects, and discover its sources.

Thiamine hydrochloride is an organic compound soluble in water but insoluble in alcohol. There are four forms of this medication for the human body, with thiamine diphosphate being the most common. The body can accumulate up to 30 g of the medication, primarily in the muscles.

Main Functions of Thiamine Hydrochloride

• Plays a crucial role in carbohydrate, fat, and protein metabolism
• Participates in ATP production (a source of intracellular energy)
• Aids in converting carbohydrate compounds into glucose (another energy source)
• Contributes to the breakdown of fats and carbohydrates
• Forms functional blood cells
• Essential for the growth and development of body systems
• Maintains stable nervous system function
• Regulates food processing
• Controls heart muscle activity
• Protects nerve cells by participating in myelin sheath formation
• Stimulates the immune system
• Enhances smooth muscle tone in the digestive system
• Stimulates the central nervous system
• Preserves visual organ health

In scientific literature, this vitamin is often referred to as an anti-stress agent. Furthermore, the weakness and lack of energy caused by thiamine deficiency can lead to apathy and depressive states.

Value of Thiamine for Athletes

B1 is an essential element for athletes and bodybuilders. It is involved in protein synthesis from dietary sources and stimulates muscle growth. To gain muscle mass, athletes need not only increased protein intake but also the right types of food.

In the absence of this vitamin, oxygen transfer to muscles is compromised, leading to reduced endurance and strength. During intense training, athletes are advised to take supplements such as thiamine bromide to enhance training performance without adverse effects.

Method of Use and Dosage

The medication is administered intramuscularly (deep into the muscle) at a dose of 25-50 mg (0.5-1 ml) once daily. Start with smaller doses, not exceeding 25 mg (0.5 ml of 5% solution), and gradually increase to 50 mg (1 ml of 5% solution) if well tolerated. The treatment course involves 10-30 injections.

Consequences of Thiamine Deficiency

Vitamin B1 is present in many foods, but its deficiency is rare. Systemic deficiency of this element can lead to severe disabilities, particularly damaging the nervous system. Conditions such as Korsakoff-Wernicke syndrome and beriberi disease, though rare, can occur.

Beri-beri causes muscle weakness, intellectual disturbances, and heart-related issues. Korsakoff syndrome is a form of beri-beri often seen in alcoholics. Prolonged encephalopathy can lead to irreversible brain damage affecting memory and mental activity.

Periodic deficiency of this vitamin in adults causes muscle atrophy, heart issues, and problems with food intake. Childhood deficiency can lead to developmental delays. While modern diets offer ample opportunities to obtain sufficient thiamine, some individuals experience prolonged deficiency, resulting in negative effects.

Symptoms of Deficiency

• Constant fatigue
• Loss of appetite
• Shortness of breath
• Apathy and depression
• Forgetfulness
• Lack of concentration
• Weakness
• Nausea
• Obstruction
• Decreased immunity
• Insomnia

If thiamine deficiency persists, more severe consequences can occur. Doctors recommend dietary adjustments and supplements in such cases.

Note that relying solely on various foods may not guarantee sufficient B1 intake. In most cases, prolonged cooking or excessive salt can cause B1 to break down. Tea, coffee, and alcohol can also diminish thiamine content. To avoid deficiency, limit consumption of these beverages.

Overdosage

Excessive consumption of vitamins can occur when not following recommended dosages. Rapid increases in concentration can lead to allergic reactions and restlessness. It’s essential to adhere to prescribed dosages.

Shelf Life

3 years.

Storage Conditions

Store in its original packaging at a temperature not exceeding 25°C. Do not freeze. Keep out of reach of children.

Incompatibility

Thiamine chloride should not be mixed with certain substances in the same syringe, including antibiotics, nicotinic acid, sulfite-containing solutions, carbonates, citrates, barbiturates, Cu2+, iodides, and tannic acid.

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Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects