Description
Vitamin C SALF 1000 mg/5 ml ampoules
Composition
Each 5 ml of Vitamin C SALF solution contains 1000 mg of ascorbic acid (Vitamin C), a water-soluble vitamin essential for multiple physiological functions.
Therapeutic Indications
Vitamin C SALF 1000 mg/5 ml is indicated for:
- Prevention and treatment of Vitamin C deficiency, including scurvy
- Supporting collagen synthesis and wound healing
- Enhancing absorption of iron from the gastrointestinal tract
- Supporting immune function during infections and inflammatory states
- Reducing oxidative stress due to its antioxidant properties
Pharmacodynamics
Ascorbic acid functions as a cofactor in enzymatic reactions, especially those involved in hydroxylation processes in collagen synthesis, catecholamine metabolism, and peptide hormone regulation. It also scavenges free radicals, contributing to cellular protection.
Pharmacokinetics
Vitamin C is rapidly absorbed in the small intestine via active transport. Plasma concentrations plateau at high intakes due to saturable absorption and renal excretion. It is distributed in all tissues, particularly high in leukocytes, pituitary gland, adrenal glands, and liver. Excess is eliminated via urine.
Dosage and Administration
- Adults: 1 to 2 ml daily (equivalent to 200–400 mg of ascorbic acid), orally.
- Children: Dosage must be determined by a healthcare professional, adjusted to body weight and deficiency severity.
It may be diluted in water or juice. Best taken after meals to reduce gastrointestinal discomfort.
Contraindications
- Known hypersensitivity to ascorbic acid or any excipients
- Patients with hyperoxaluria or history of oxalate kidney stones
- Severe renal impairment without medical supervision
Precautions
- Use caution in patients with renal dysfunction or predisposition to nephrolithiasis
- High doses may cause hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Long-term high doses may increase uric acid levels and contribute to oxalate stone formation
Overdosage
Symptoms of overdose may include:
- Nausea, vomiting, and abdominal pain
- Osmotic diarrhea
- Hemolytic anemia in G6PD-deficient individuals
- Kidney stone formation (particularly oxalate stones)
Seek medical attention immediately in cases of suspected overdose.
Adverse Reactions
- Common: Gastrointestinal disturbances (diarrhea, cramps)
- Uncommon: Headache, flushing, insomnia
- Rare: Allergic reactions, oxalate nephropathy, hematuria
Drug Interactions
- May reduce efficacy of some chemotherapy agents (e.g., doxorubicin)
- High doses may affect the action of warfarin and increase absorption of aluminum from antacids
- May interfere with certain laboratory tests (e.g., glucose testing, fecal occult blood)
Pregnancy and Lactation
Vitamin C is considered safe during pregnancy and lactation when taken within recommended daily allowances. High doses should be avoided unless prescribed. Excessive maternal intake may increase risk of rebound scurvy in newborns.
Storage
- Store at 15°C–25°C (59°F–77°F), protected from light and heat
- Do not freeze
- Keep out of reach of children
Package and Presentation
Vitamin C SALF 1000 mg/5 ml is supplied in a 100 ml amber glass bottle with dropper for accurate measurement. Designed for oral administration.
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