Description

Enerion (Sulbutiamine) Tablets 200 mg, Pack of 20

Composition

Each tablet contains 200 mg of sulbutiamine, a synthetic derivative of thiamine (vitamin B1). Inactive ingredients include lactose monohydrate, povidone, magnesium stearate, and sodium starch glycolate.

Pharmacological Group

Enerion belongs to the pharmacological group of neurotropic and nootropic agents. It is used primarily for its central nervous system (CNS) stimulating and anti-asthenic properties.

Pharmacological Properties

Sulbutiamine exhibits enhanced bioavailability compared to thiamine and effectively crosses the blood-brain barrier. It promotes cholinergic and glutamatergic activity, improving mental performance, alertness, and mood. Studies suggest its efficacy in reducing fatigue and enhancing cognitive function in patients with asthenic or neuropsychiatric conditions.

Indications

• Symptomatic treatment of functional asthenia (physical and/or mental fatigue)
• Supportive therapy in chronic fatigue and mild cognitive impairment
• Adjunct treatment in thiamine deficiency states: beriberi, Wernicke’s encephalopathy, Korsakoff’s syndrome
• Possible off-label use in depressive symptoms and memory impairment

Contraindications

• Known hypersensitivity to sulbutiamine or any excipients
• Children and adolescents under 18 years of age
• Pregnancy and breastfeeding (unless prescribed)
• Severe renal impairment

Precautions

• Use with caution in patients with bipolar disorder or psychosis due to CNS stimulation
• Monitor in elderly patients or those with a history of substance abuse
• May exacerbate anxiety or insomnia in sensitive individuals

Drug Interactions

• May interact with MAO inhibitors, tricyclic antidepressants, or antipsychotic agents
• Possible synergistic effect with stimulants or cholinergic nootropics
• Consult your healthcare provider before combining with other cognitive enhancers or psychiatric medications

Dosage and Administration

Recommended adult dosage: 400–600 mg per day (2–3 tablets), taken orally with water. Preferably administered in the morning and early afternoon to reduce risk of insomnia. Duration of treatment is typically 2–4 weeks, but may be adjusted depending on therapeutic response.

Adverse Reactions

• Common: headache, irritability, nausea, insomnia, agitation
• Less common: rash, allergic reactions, palpitations
• Rare: severe hypersensitivity reactions (facial swelling, dyspnea), especially in predisposed individuals

Overdose

Symptoms of overdose may include anxiety, gastrointestinal upset, tremor, and insomnia. No specific antidote exists. Management is symptomatic and supportive. Seek immediate medical assistance if overdose is suspected.

Scientific References

• Blanchard J, et al. “Sulbutiamine: a review.” Drugs of Today (2002)
• Joubert C, et al. “Use of sulbutiamine in chronic fatigue.” Presse Med (2008)

Storage

Store at 15–25°C (59–77°F) in a dry place, protected from light and moisture. Keep out of reach of children.

Disclaimer

This information is intended for educational purposes only and does not replace medical advice. Always consult your physician or pharmacist before starting any new medication.