Description

Iruxol Ointment 30 g, Tube

Composition

Each gram of Iruxol ointment contains:

Collagenase – 10,000 units
Chloramphenicol – 100,000 units

Inactive ingredients include petrolatum, sorbitan sesquioleate, and lanolin alcohols.

Therapeutic Indications

Iruxol is indicated for enzymatic debridement of chronic dermal ulcers, necrotic wounds, and severe burns. The collagenase component facilitates the removal of necrotic tissue by selectively breaking down denatured collagen, thus promoting natural wound healing. Chloramphenicol provides a broad-spectrum antibacterial effect, helping to prevent secondary infections.

Pharmacological Properties

Collagenase is a proteolytic enzyme that hydrolyzes collagen in necrotic tissues, facilitating the breakdown and removal of eschar without harming healthy tissue. Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. This dual-action mechanism aids both in wound cleaning and infection control.

Dosage and Administration

Cleanse the wound thoroughly and remove loose debris.
Apply a thin layer of Iruxol directly to the necrotic tissue once or twice daily.
The wound should be covered with a moist dressing.
Treatment should continue until satisfactory debridement has been achieved.
Wash hands before and after application.

Contraindications

Hypersensitivity to collagenase, chloramphenicol, or any excipients in the formulation
Presence of systemic infection or local infection at the wound site not appropriately managed
Concurrent use with silver- or iodine-based antiseptics (e.g., silver sulfadiazine) due to enzyme inactivation

Warnings and Precautions

Topical use only. Avoid contact with eyes, mucosa, and healthy surrounding skin.
Use with caution in patients with blood dyscrasias due to the presence of chloramphenicol, which has been associated with rare but serious adverse hematologic effects including aplastic anemia.
Limit duration of use and monitor for local and systemic adverse reactions.

Interactions

Collagenase activity is inhibited by heavy metal ions and antiseptics such as silver, iodine, or hydrogen peroxide. Do not use Iruxol concurrently with these substances.

Pregnancy and Lactation

There are insufficient data regarding the safety of Iruxol in pregnancy and lactation. Use only if the expected therapeutic benefit outweighs the potential risk. Consult a healthcare provider before use.

Effects on Ability to Drive and Use Machines

Iruxol does not affect alertness or motor skills and has no influence on the ability to drive or operate machinery.

Adverse Reactions

Common: Local irritation at the site of application (e.g., redness, swelling, burning sensation, itching)
Uncommon: Delayed wound healing, rash
Rare: Systemic hypersensitivity reactions, such as anaphylaxis or bone marrow suppression (due to chloramphenicol)

Overdose

Topical overdose is unlikely to cause systemic toxicity. Accidental ingestion may cause gastrointestinal upset and requires symptomatic treatment. Seek medical attention immediately if overdose is suspected.

Storage

Store below 25°C in a dry place, away from direct sunlight. Do not refrigerate or freeze. Keep out of reach of children. Do not use beyond the expiry date.

Packaging

Available in a 30 g aluminum tube, sealed and labeled for external use only.

Instructions for Use

Clean the wound using saline or an appropriate wound cleanser.
Apply a thin film of Iruxol to the wound surface, avoiding surrounding healthy skin.
Cover with a suitable dressing that maintains moisture (e.g., hydrogel or non-adhesive gauze).
Reapply once or twice daily based on clinical response or as directed by a physician.

References

Disclaimer

This information is intended for educational purposes only and does not substitute for the advice of a licensed healthcare provider. Always follow the instructions of your doctor or pharmacist when using prescription medications.

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