Description

Iruxol ointment 30 g, tube

Active ingredients: clostridiopeptidase, chloramphenicol.

Inactive ingredients: paraffin oil, white petrolatum.

The medication is produced in the form of ointment, poured into tubes of 30 grams, where 1 gram contains 10 mg of chloramphenicol and 0.6 U of clostridiopeptidase.

Iruxol Pharmacological Properties

Iruxol belongs to the group of medications intended for topical use.

Chloramphenicol, the active ingredient of Iruxol, belongs to synthetic antibiotics. This component is effective for treating wounds and skin, exerting a beneficial effect by enzymatically cleansing necrotic tissues and purulent secretions. It can block protein synthesis in cells of pathological microorganisms, leading to their death. It also provides a bacteriostatic effect against various microorganisms that are pathological for humans.

Thanks to the use of this medication, necrotic tissues are softened, wounds are gently cleansed without mechanical damage, and healthy tissues are not adversely affected.

Iruxol Indications

Iruxol is intended for cleansing necrotic tissue from wounds of various origins and locations. It is effective for the treatment of:

• Long-term healing wounds, infected and postoperative wounds, radiation skin damage, traumatic soft tissue injuries.
• Ulceration and necrosis, including varicose ulcers, pressure ulcers, burns of second and third degree, gangrene of the extremities (especially diabetic), and frostbite.

It is also used as a skin-care medication before transplantation.

Iruxol Contraindications

This medical product should not be used if the patient has a history of hypersensitivity (allergy) to any of its components. It is also contraindicated in cases of:

• Collagenoses
• Hematopoietic organ diseases
• Severe kidney and liver damage
• Psoriasis, eczema, fungal skin diseases

In pediatrics, it is used to treat children who are at least 12 years old.

 

Method of Use and Dosage

The exact dosage and treatment duration are determined by the attending physician. Typically, the ointment is applied once a day; in severe cases, it can be applied twice a day. The treatment course usually lasts from 5 to 10-14 days.

The ointment layer’s thickness should be about the size of a knife blade. It’s permissible to make incisions on necrotic tissue to aid ointment penetration. It’s advisable not to dry the tissues before applying the ointment; instead, soften them with compresses.

Softened and exfoliated tissue should be removed before each new ointment application using medical procedures and instruments, with mandatory antiseptic treatment. After cleansing the wound from necrotic tissue, the ointment is applied, and other medications are prescribed to enhance the epithelialization and granulation processes. It can be used under a bandage.

Overdosage

Overdosage with the medication is unlikely due to its low degree of tissue absorption. Prolonged use of the ointment, however, can lead to allergic reactions.

Side Effects

Using this medication can cause local irritating reactions, such as a burning sensation and temporary pain. In some cases, an allergic reaction to chloramphenicol can occur, leading to contact dermatitis, redness, swelling, itching, or exanthema. These symptoms typically disappear after stopping treatment.

Additionally, with prolonged use, systemic reactions may occur in the form of:

• Aplastic anemia
• Leukopenia
• Thrombocytopenia

Storage Terms and Conditions

This medicinal product retains its effectiveness for 5 years from the date of manufacture, as specified by the manufacturer. Keep the medication out of reach of children and store it within a temperature range of 15 to 25°C.

---

Wound healing with Iruxol. Results of a multicenter study