Description

Corvalment Capsules 100 mg, #80

Composition

Each capsule of Corvalment contains 100 mg of menthyl isovalerate, the active substance known for its vasodilatory and sedative properties. The preparation is presented in soft gelatin capsules. Inactive ingredients may vary by manufacturer but typically include gelatin, glycerol, and purified water.

Description

Corvalment is a modern alternative to Corvalol or Valocordin, offering similar calming and vasodilatory effects without alcohol or barbiturates. It is frequently used in Eastern Europe for functional cardiac disorders, neurotic states, and mild forms of anxiety. Unlike many sedatives, it does not induce physical dependence or significant drowsiness in therapeutic doses.

Mechanism of Action

Menthyl isovalerate, the active ingredient in Corvalment, is a derivative of valerian acid combined with menthol. It acts as a mild sedative and spasmolytic, helping to relieve tension in the central and peripheral nervous systems. The combination of menthol’s cooling effect with the sedative action of isovalerate contributes to a calming influence on the cardiovascular system, reduces perception of stress, and supports normalization of sleep and heart rate.

Indications

Corvalment is indicated for:

• Functional cardiovascular disorders (e.g., mild tachycardia, cardialgia)
• Neurotic and anxiety states
• Sleep disturbances related to nervous tension
• Mild vasospasms (e.g., headaches or stress-induced vascular reactions)

Dosage and Administration

Adults are typically advised to take 1 capsule (100 mg) 2 to 3 times daily. In cases of acute stress or mild sleep disturbance, 2 capsules may be taken once in the evening. Capsules should be swallowed whole with water after meals. Treatment duration is usually short-term (up to 14 days), but longer use may be allowed under medical supervision.

Contraindications

• Hypersensitivity to menthol, valerian derivatives, or any capsule components
• Severe hypotension or bradycardia
• Severe hepatic or renal impairment
• Children under 12 years of age
• Pregnancy and lactation (unless deemed necessary by a physician)

Precautions

Use with caution in individuals with hypotension, autonomic nervous system disorders, or those taking antihypertensive or sedative medications. Do not exceed recommended dosage to avoid CNS depression or hypotensive episodes. Avoid driving or operating machinery until individual sensitivity is assessed.

Side Effects

Corvalment is generally well tolerated. Possible adverse effects may include:

• Mild dizziness or fatigue
• Gastrointestinal discomfort
• Allergic reactions (rash, itching, urticaria)

If side effects occur or persist, discontinue use and consult a physician.

Drug Interactions

Corvalment may enhance the effects of other CNS depressants, sedatives, beta-blockers, and antihypertensives. Alcohol consumption can potentiate sedative effects. Concurrent use with strong sedatives or barbiturates should be avoided.

Overdose

Symptoms of overdose include marked sedation, hypotension, dizziness, and bradycardia. In severe cases, CNS depression and respiratory difficulties may occur. Treatment is symptomatic: maintain airway patency, monitor cardiovascular and CNS function, and provide supportive measures as needed.

Storage

Store at a temperature between 15°C and 25°C (59°F to 77°F), away from moisture and light. Keep out of reach of children. Do not use beyond the expiration date printed on the packaging.

Scientific References

• Menthyl isovalerate in the treatment of anxiety-related cardiovascular symptoms (PubMed)
• Phytotherapeutic agents and their cardiovascular effects (NCBI)

Disclaimer

This material is for informational purposes only and does not substitute medical advice. Always consult your healthcare provider before starting or changing medication. The effects of Corvalment may vary between individuals.