Description

Dona Sachets 1500 mg, Pack of 20 – Glucosamine Sulphate

Composition

Each sachet of Dona contains 1500 mg of Glucosamine Sulphate as the active ingredient. Excipients include aspartame, sorbitol, citric acid, and orange flavoring.

Pharmacological Group

Dona belongs to the group of non-steroidal anti-inflammatory and antirheumatic products. It is a non-opioid analgesic used primarily in degenerative joint disorders.

Therapeutic Indications

Dona is indicated for the symptomatic relief of osteoarthritis, including reduction of joint pain, stiffness, and inflammation. It is commonly used in the management of mild to moderate osteoarthritis of the knee, hip, and small joints of the hands.

Mechanism of Action

Glucosamine sulfate supports cartilage metabolism by enhancing the synthesis of proteoglycans and hyaluronic acid in synovial fluid. It also inhibits catabolic enzymes and mediators involved in joint degradation, helping to preserve joint function and mobility.

Contraindications

• Known hypersensitivity to glucosamine or any excipients in the formulation
• Phenylketonuria (contains aspartame)
• Severe renal or hepatic impairment

Precautions

• Use with caution in diabetic patients due to possible effects on blood glucose levels
• Patients with asthma or those prone to allergic reactions should use glucosamine under medical supervision
• Monitor patients with gastrointestinal disorders (e.g., peptic ulcers)

Drug Interactions

• Warfarin: May increase INR and bleeding risk
• NSAIDs and corticosteroids: Concurrent use may enhance GI side effects
• May interfere with lab tests for liver function and blood sugar

Dosage and Administration

Recommended dose: One sachet (1500 mg) once daily. Dissolve contents in a glass of water and consume immediately. It can be taken with or without food. Treatment duration varies depending on the severity of symptoms but often requires continuous use over several weeks or months for full effect.

Side Effects

• Common: Nausea, dyspepsia, constipation, diarrhea, abdominal pain
• Less common: Headache, dizziness, skin rash, pruritus
• Rare: Elevated liver enzymes, allergic reactions

Overdose

Symptoms of overdose may include gastrointestinal discomfort, drowsiness, and hypotension. Treatment is symptomatic. Seek emergency medical attention if overdose is suspected.

Package and Storage

Dona 1500 mg is packaged in 20 individually sealed sachets per box. Store at room temperature (15–25°C), away from direct heat, light, and moisture. Keep out of reach of children.

Manufacturer

Manufactured by Rottapharm, a global pharmaceutical company known for research and development in the field of musculoskeletal and joint health.

Scientific References

• Reginster JY. “Glucosamine sulfate significantly reduces progression of knee osteoarthritis.” Arthritis Rheum. 2001.
• Towheed TE, et al. “Glucosamine therapy for treating osteoarthritis.” Cochrane Database Syst Rev. 2005.

Disclaimer

The information provided here is for educational purposes only and should not replace medical advice. Always consult your healthcare provider before beginning any new treatment or supplement regimen.