Description

Magnesium sulfate 250 mg/ml 10 amp 5 ml.

Indications:

• Hypertensive crisis
• Ventricular arrhythmias (specifically tachycardia type “pirouette”)
• Convulsive syndrome
• Eclampsia
• Hypomagnesemia
• Increased need for magnesium
• Complex therapy of premature births
• Angina pectoris
• Poisoning by salts of heavy metals (such as tetraethyl lead and soluble barium salts) as an antidote

Contraindications:

• Hypersensitivity to the components of the drug
• Hypotension
• Severe bradycardia (heart rate less than 55 beats/min)
• Atrioventricular block
• Conditions caused by calcium deficiency and respiratory depression
• Cachexia
• Renal dysfunction
• Severe hepatic or renal failure
• Myasthenia gravis
• Malignant neoplasms

Interaction with Other Medicinal Products and Other Forms of Interaction:

• • Calcium ions have an antagonistic effect against magnesium ions, reducing the pharmacological effects of magnesium sulfate when used together.

Method of Application and Dosage:

Administer intramuscularly, intravenously slowly, or as an intravenous infusion. The frequency and dose of administration are individual and depend on the indication and therapeutic effect. When using infusion, the drug should be diluted with 0.9% sodium chloride solution or 5% glucose. For intravenous injection, the rate of administration should not normally exceed 150 mg/min (0.6 ml/min), except in the treatment of arrhythmias and eclampsia in pregnant women.

Hypomagnesemia:

In moderate hypomagnesemia (0.5-0.7 mmol/l), adults should be administered 4 ml (1 g of magnesium sulfate) intramuscularly every 6 hours. In severe hypomagnesemia (<0.5 mmol/l), the total dose should be increased to 1 ml/kg (250mg/kg) administered intramuscularly in portions over 4 hours. For severe hypomagnesemia, an intravenous infusion can be used by adding 20 ml of the drug (5 g of magnesium sulfate) to 1 liter of 0.9% sodium chloride solution or 5% glucose, and it should be administered for at least 3 hours.

Magnesium Sulfate Overdose

Symptoms of overdose may include:

• • Reduction of deep tendon reflexes (2-3.5 mmol/l)

Treatment: The specific antidote for magnesium sulfate overdose is calcium supplements (calcium chloride or gluconate), which should be administered intravenously slowly. Furosemide may be prescribed for moderate hypermagnesemia. Respiratory depression should be addressed by intravenous administration of 5-10 ml of 10% calcium chloride solution, oxygen inhalation, or artificial lung ventilation. In severe cases, peritoneal dialysis or hemodialysis may be necessary. Symptomatic drugs that correct the functions of the cardiovascular and central nervous systems can also be prescribed.

Expiration date: 5 years.

Storage conditions: Store in the original package at a temperature not exceeding 25°C. Do not freeze. Keep out of reach of children.

Incompatibility: Magnesium sulfate is pharmaceutically incompatible (precipitate formed) with calcium preparations, high concentrations of ethanol, carbonates, bicarbonates, alkali metal phosphates, salts of arsenic acid, barium, strontium, clindamycin phosphate, hydrocortisone sodium succinate, succinate, polycinate, and polycinnamate. When concentrations of Mg2+ exceed 10 mmol/ml in mixtures for complete parenteral nutrition, the distribution of fat emulsions may occur.

Packaging:

10 ml in an ampoule; 5 ampoules in a contour honeycomb package; 2 contour honeycomb packages in a pack.

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Magnesium sulphate in the treatment of eclampsia and pre-eclampsia: an overview of the evidence from randomised trials