Description

Testosterone Propionate 50 mg/ml – 5 Ampoules

Composition

Each 1 ml ampoule contains:

Testosterone Propionate – 50 mg
Excipients: Benzyl Alcohol (preservative), Benzyl Benzoate (solubilizer), Refined Peanut Oil (vehicle)

Indications

Testosterone Propionate is indicated for testosterone replacement therapy in males with confirmed testosterone deficiency due to congenital or acquired conditions, including:

Primary hypogonadism (testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, or orchiectomy)
Hypogonadotropic hypogonadism (congenital or acquired)
Delayed puberty in adolescent males (under specialized supervision)
Inoperable metastatic breast cancer in females (as palliative treatment)

Mechanism of Action

Testosterone Propionate is a short-acting ester of the endogenous androgen testosterone. It acts via androgen receptors to stimulate protein synthesis, muscle growth, erythropoiesis, libido, and the development/maintenance of male secondary sexual characteristics. It also modulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) through negative feedback on the hypothalamic-pituitary-gonadal axis.

Dosage and Administration

Route: Deep intramuscular injection into the gluteal muscle
Typical adult dosage: 25–50 mg every 2–3 days
Adjustment: Based on serum testosterone levels and clinical response
Monitoring: Evaluate testosterone levels, hematocrit, liver function, and PSA regularly

Contraindications

Known or suspected carcinoma of the prostate or male breast
Hypersensitivity to testosterone or formulation excipients
Women who are pregnant or may become pregnant (teratogenic risk)
Severe hepatic, cardiac, or renal impairment (due to fluid retention risk)

Warnings and Precautions

Monitor hematocrit (risk of polycythemia), especially in elderly patients
Use with caution in patients with sleep apnea, benign prostatic hyperplasia (BPH), or hypertension
May increase risk of prostate hypertrophy or prostate cancer – monitor PSA levels
May impair fertility due to suppression of gonadotropins

Adverse Reactions

Local: Pain, redness, or swelling at injection site
Systemic: Gynecomastia, oily skin, acne, increased libido or aggression, fluid retention
Endocrine: Suppression of spermatogenesis, alterations in lipid profile, polycythemia

Drug Interactions

Oral anticoagulants: Increased anticoagulant effect – monitor INR
Insulin or antidiabetics: Enhanced hypoglycemic response
Glucocorticoids: Increased risk of fluid retention and edema

Overdose

Acute overdose is unlikely to cause life-threatening events. In case of excessive dosing, symptoms may include increased hematocrit, mood changes, or libido fluctuations. Therapy should be interrupted and resumed at a lower dose after clinical assessment.

Clinical Evidence

Storage

Store at 15–25°C (59–77°F)
Protect from light and moisture
Keep out of reach of children
Do not use if solution is cloudy or contains particles

Disclaimer

This product is a prescription-only medication. It should only be used under the supervision of a qualified healthcare provider after confirmation of testosterone deficiency. Do not use for body-building or performance enhancement without medical justification, as misuse can result in serious health risks.

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