Description

Pregnyl Vials, 5000 IU, #1 Solution

Composition

Each vial of Pregnyl contains 5000 International Units (IU) of Human Chorionic Gonadotropin (hCG), a glycoprotein hormone produced naturally during pregnancy. The formulation also includes inactive ingredients such as mannitol and sodium phosphate to stabilize the lyophilized powder for reconstitution.

Description

Pregnyl is presented as a lyophilized powder that must be reconstituted before intramuscular or subcutaneous injection. It is used in fertility treatment regimens to promote ovulation in women and stimulate testosterone production or increase sperm count in men. In boys, it can be used to address cryptorchidism (undescended testicles).

Pharmacological Action

hCG mimics the action of luteinizing hormone (LH). In women, it stimulates ovulation by inducing the final maturation of ovarian follicles. In men, it promotes the production of testosterone by acting on the Leydig cells of the testes, which supports spermatogenesis and development of male secondary sexual characteristics.

Indications

• Induction of ovulation in anovulatory women
• Treatment of male infertility caused by hypogonadotropic hypogonadism
• Stimulation of testicular descent in boys with delayed puberty and cryptorchidism

Dosage and Administration

Dosage must be individualized and administered by a healthcare provider. Example regimens include:

• Women (Ovulation Induction): 5000–10,000 IU one day after the last dose of follicle-stimulating hormone (FSH)
• Men (Hypogonadism): 500–1000 IU three times a week for several weeks
• Boys (Cryptorchidism): 500–4000 IU three times weekly for 3 weeks

Contraindications

• Known hypersensitivity to hCG or any excipient
• Prostate carcinoma or androgen-dependent tumors
• Uncontrolled thyroid or adrenal dysfunction
• Ovarian cysts not related to PCOS
• Precocious puberty

Side Effects

Common side effects include:

• Injection site pain
• Headache
• Irritability
• Fatigue

Serious adverse effects include:

• Ovarian hyperstimulation syndrome (OHSS)
• Pelvic pain
• Edema
• Shortness of breath

Interactions

Potential interactions may occur with gonadotropin-releasing hormone (GnRH) analogs and other hormonal treatments. Inform your physician about all medications and supplements prior to use.

Precautions

• Increased risk of multiple gestations (twins or more)
• Monitor for signs of OHSS in women
• Use with caution in patients with asthma, cardiac, renal, or epileptic conditions

Storage

• Store unreconstituted vials at 2°C to 8°C (36°F to 46°F)
• Do not freeze
• Once reconstituted, use immediately and discard any unused solution

Overdose

Signs of overdose may include nausea, vomiting, abdominal pain, and OHSS symptoms. Immediate medical attention is necessary.

Scientific References

• Human Chorionic Gonadotropin and its Clinical Use – NCBI
• Pregnyl Prescribing Information – Drugs.com

Conclusion

Pregnyl 5000 IU is an effective hormone therapy for ovulation induction, male infertility, and delayed puberty in boys. As with any hormone therapy, medical supervision, proper dosing, and monitoring are essential to ensure effectiveness and minimize risks.