Description

Thiamine Hydrochloride (Vitamin B1) 50 mg/ml, 1ml Ampoules, Pack of 10

Composition

Each 1 ml ampoule contains 50 mg of Thiamine Hydrochloride (Vitamin B1). Excipients include sterile water for injection and pH-stabilizing agents. The product is supplied in a package of 10 ampoules (1 ml each).

Description

The medicine is the water-soluble form of vitamin B1, a vital micronutrient involved in carbohydrate metabolism and neural function. It is essential for the decarboxylation of alpha-keto acids and the hexose monophosphate shunt. The human body cannot synthesize thiamine, making external supplementation crucial, especially under deficiency or increased demand.

Indications

• Treatment and prevention of thiamine deficiency (e.g., beriberi, Wernicke’s encephalopathy)
• Chronic alcoholism-related neuropathy
• Supportive therapy in critical illness with suspected micronutrient deficiency
• Adjunctive therapy in conditions like heart failure or prolonged vomiting
• Post-bariatric surgery nutritional support

Dosage and Administration

It is administered via intramuscular (IM) or slow intravenous (IV) injection by a healthcare professional. Standard adult doses:

• Prophylaxis: 5–30 mg daily
• Therapeutic (moderate deficiency): 30–100 mg daily
• Severe deficiency (e.g., Wernicke’s encephalopathy): up to 500 mg IV three times daily

Dosage may be adjusted depending on clinical condition, comorbidities, and physician discretion.

Contraindications

• Known hypersensitivity to the active substance or formulation components
• History of anaphylactic reaction to injectable form

Precautions

• Use with caution in patients with cardiovascular disorders; rapid IV injection may cause hypotension or arrhythmia
• Injection should be administered slowly to minimize risk of adverse reactions
• Use during pregnancy and lactation only when clearly needed

Adverse Reactions

Although rare, injectable form may cause:

• Allergic reactions: rash, pruritus, urticaria, anaphylaxis
• Local reactions: pain or redness at injection site
• Systemic: nausea, restlessness, sweating, hypotension

Overdosage

No significant toxicity reported with high doses of thiamine due to its water-soluble nature. However, symptoms such as dizziness, hypotension, and nausea may occur. Supportive care is indicated in such cases.

Pharmacology

Once administered, thiamine is rapidly absorbed and converted to its active coenzyme form, thiamine pyrophosphate (TPP), which facilitates enzymatic reactions in glucose metabolism. TPP plays a key role in neural function by maintaining myelin sheath integrity and neurotransmitter synthesis.

Drug Interactions

• Loop diuretics (e.g., furosemide) may increase thiamine excretion
• Alcohol reduces intestinal absorption of thiamine
• No clinically significant drug-drug interactions noted for parenteral thiamine

Storage

• Store at 15–25°C (59–77°F)
• Protect from light and freezing
• Discard if the solution appears cloudy or contains precipitate

Scientific References

• Thiamine deficiency and its prevention and control in major emergencies — WHO
• Thiamine (Vitamin B1) – StatPearls, NCBI Bookshelf