Polyoxidonium is a pharmaceutical product containing the active ingredient azoximer bromide. It is designed to strengthen the immune system and enhance the body’s ability to produce antibodies.

Polyoxidonium is used in the treatment of conditions involving immune system suppression, such as infections and regeneration processes.

It comes in various forms, including injections and tablets, and can be beneficial for individuals with immunodeficiency, purulent-septic diseases, fractures, burns, and more.

Active Ingredient

Each vial contains 6 mg of polyoxidonium (azoximer bromide).

Inactive Ingredients

• Mannitol (E 421)
• Povidone
• Betacarotene

Pharmaceutical Dosage Form

Lyophilisate – Solution for Injections.

Basic Physicochemical Properties

Polyoxidonium is a derivative of a copolymer of N-oxide poly-1,4-ethylenepiperosine and (N-carboxymethyl), -1,4 ethylenepiperosinium bromide. It is a porous mass ranging from white to yellow color. It is soluble in water, aqueous sodium chloride solution, and novocaine. The substance is hygroscopic with a molecular weight of 60,000 to 100,000.

Pharmacological Effect

Polyoxidonium is a medication that strengthens the human immune system and actively promotes the production of antibodies. It improves treatment for people with immunodeficiency. When taken for various diseases, it extends remission periods and enhances resistance to infections.

Indications and Usage

Polyoxidonium is used in complex treatment for conditions and diseases involving immune system suppression. It is utilized in cases of purulent-septic diseases, viral and bacterial infections, and for activating regeneration processes in fractures, burns, and necrosis.

Method of Use and Dosage

Administered subcutaneously or intramuscularly, 6-12 grams once per day. The treatment course consists of 5-10 injections. Prolonged courses (2-3 months) may require 6-12 grams once a week. Before injection, the medicine is dissolved in isotonic sodium chloride solution, distilled water, or 0.25-0.5% novocaine solution.

Contraindications

Intolerance to polyoxidonium.

Use during Pregnancy and Lactation

Not recommended.

Overdosage

No cases of overdosage have been reported with this pharmaceutical product.

Polyoxidonium Side Effects

Occasionally, painful sensations were noticed when the medication was taken intramuscularly.

Storage Terms and Conditions

Shelf life is 2 years. Store at a temperature range of +4 to +15°C.

The safety profile of Polyoxidonium in daily practice: results from postauthorization safety study in Slovakia