Description

Pyridoxine (Vitamin B6) Vials 50 mg/ml, 1 ml, #10

Composition

Each 1 ml vial contains 50 mg of pyridoxine hydrochloride (Vitamin B6) as the active ingredient. Inactive components may include sterile water for injection, sodium chloride, and occasionally preservatives depending on the manufacturer.

Description

Pyridoxine is a water-soluble B-vitamin essential for protein metabolism, neurotransmitter synthesis, and red blood cell formation. This injectable form is used in clinical settings for individuals requiring rapid or high-dose replenishment.

Pharmacological Group

Belongs to the group of vitamins and nutritional supplements. Acts as a coenzyme in many enzymatic reactions in amino acid, glucose, and lipid metabolism.

Indications

• Treatment and prevention of peripheral neuropathy caused by drugs (e.g., isoniazid, hydralazine, penicillamine)
• Hereditary metabolic disorders (e.g., homocystinuria, xanthurenic aciduria, cystathioninuria)
• Supportive therapy in sideroblastic anemia, morning sickness, seizures in infants due to deficiency
• Vitamin B6 deficiency due to malnutrition, alcoholism, or malabsorption

Mechanism of Action

Pyridoxine is converted in the body to its active form, pyridoxal 5′-phosphate, which functions as a coenzyme in various enzymatic processes, including neurotransmitter synthesis (serotonin, dopamine, GABA), amino acid metabolism, and homocysteine breakdown.

Dosage and Administration

• Usual adult dose: 50–100 mg per day intramuscularly or subcutaneously
• Dosage may be increased in cases of drug-induced deficiency or metabolic disorders
• Administered by a healthcare professional

Contraindications

• Hypersensitivity to pyridoxine or any component of the formulation
• Severe hepatic dysfunction (caution advised)

Side Effects

• Common: Nausea, headache, drowsiness, tingling, burning, or numbness in hands or feet
• Rare: Photosensitivity, allergic skin reactions, peripheral sensory neuropathy (at high doses over long duration)

Drug Interactions

• Reduces efficacy of levodopa (unless combined with a decarboxylase inhibitor)
• May interact with cycloserine, hydralazine, isoniazid, and penicillamine (increasing need for B6)

Precautions

• Use caution in patients with renal insufficiency or severe cardiovascular disease
• Neuropathy risk increases with prolonged high-dose use (>200 mg/day)

Overdose

Chronic overdose may lead to sensory neuropathy, ataxia, and loss of coordination. Acute overdose symptoms include nausea, drowsiness, and confusion. Supportive treatment is recommended.

Pregnancy and Lactation

• Pregnancy: Pyridoxine is considered safe in doses up to 100 mg/day. High doses should only be used under medical supervision.
• Lactation: Excreted in breast milk. No adverse effects reported in nursing infants when used at recommended doses.

Storage

• Store at 15–30°C (59–86°F)
• Protect from light and moisture
• Keep out of reach of children

Scientific References

• Bender DA. “Vitamin B6 – beyond coenzyme functions.” Subcell Biochem. 2020.
• Leklem JE. “Vitamin B6: a status report.” J Nutr. 1990.