Clomiphene citrate (clostilbegyt) tablets 50 mg, #10

Description

Clomiphene citrate (clostilbegyt) tablets 50 mg, #10

Composition

Each tablet of Clomiphene citrate (clostilbegyt) contains 50mg of the active ingredient, Clomiphene citrate. The medication is supplied in a pack of 10 tablets. Other inactive ingredients include lactose monohydrate, magnesium stearate, starch, and polyvinyl alcohol among others to aid in the formulation of the tablet.

Description

Clomiphene citrate (clostilbegyt) is a non-steroidal fertility medication used to treat ovulatory dysfunction and polycystic ovary syndrome in women who desire pregnancy. It is considered a first-line treatment for these conditions, and it is also utilized in certain cases of unexplained infertility.

Mechanism of Action

Clomiphene citrate functions by stimulating an increase in the amount of hormones that support the growth and release of a mature egg (ovulation). Specifically, it blocks the action of estrogen at the hypothalamus, resulting in an increase in the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland, which in turn stimulate the ovaries to mature and release eggs.

Indications

This medication is typically indicated for women with ovulatory dysfunction or polycystic ovary syndrome desiring pregnancy. It may also be used in cases of unexplained infertility or in combination with other treatments as part of assisted reproductive technology procedures.

Contraindications

Clomiphene citrate is contraindicated in patients with a hypersensitivity to clomiphene citrate or any of the inactive ingredients in the formulation. It is also contraindicated in patients with liver disease or a history of liver dysfunction, abnormal uterine bleeding of undetermined origin, ovarian cysts or enlargement not due to polycystic ovary syndrome, uncontrolled thyroid or adrenal dysfunction, or an uncontrolled pituitary tumor.

Dosage and Administration

The recommended dose for the first course of Clomiphene citrate (clostilbegyt) is 50 mg (1 tablet) daily for 5 days. Therapy may be started at any time in the patient who has had no recent uterine bleeding. If ovulation appears not to have occurred after the first course of therapy, a second course of 100 mg daily (two 50 mg tablets given as a single daily dose) for 5 days should be given. This course may be started as early as 30 days after the previous one.

Side Effects

Common side effects of Clomiphene citrate include hot flashes, abdominal discomfort, bloating, nausea, and vomiting. Less common side effects may include breast tenderness, headache, abnormal uterine bleeding, and visual disturbances. In rare cases, ovarian hyperstimulation syndrome may occur, which can cause severe abdominal pain, bloating, weight gain, and difficulty breathing.

Precautions

Patients should be advised of the potential risks of multiple pregnancies before starting treatment with Clomiphene citrate. In addition, patients should be warned that visual symptoms may occur during or shortly after therapy, and they should be advised to refrain from activities where these symptoms could be dangerous, such as driving or operating heavy machinery.

Overdose

In the event of an overdose, symptoms such as nausea, vomiting, flushing, blurred vision, visual spots or flashes, and abdominal pain may occur. There is no specific antidote, and treatment should be symptomatic and supportive. If necessary, the patient should be hospitalized for close observation and management.

Storage

Clomiphene citrate (clostilbegyt) tablets should be stored at room temperature, away from light and moisture. Keep out of reach of children and pets.

Disclaimer

This information is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Always consult your healthcare provider before starting any new medication or changing your current regimen.